non gestational choriocarcinoma
Primary ovarian choriocarcinoma is a rare malignant tumor, can be divided into pregnancy and non-gestational categories. Gestational choriocarcinoma is from ovarian pregnancy; non-gestational choriocarcinoma cell lines derived from the germ. This section will discuss only the latter increases. Non-gestational ovarian choriocarcinoma is a highly malignant germ cell tumors, often invading into adjacent organs and tissues, extensive transfer easily a poor prognosis.
Diagnosis is based on
(A) clinical manifestations occur in children and young women. In addition to germ cell tumors and other clinical symptoms seen in the same, but there have HCG as tumor characteristics, it can induce ovarian development of children, clinical manifestations of precocious puberty. Breast, and she begins development, genital and axillary hair growth, and vaginal bleeding. If the tumor occurs in sexually mature women, they appear similar to the ectopic pregnancy (also known as ectopic pregnancy) symptoms.
(B) of the pathological examination
1. Giant unilateral inspection of medium size, solid, surface white, and often covered with a thin layer of capsule, often subcapsular hemorrhage. Section for the loose material, purple tissue, crisp and easy bleeding.
2. Microscopic examination by the cytotrophoblast cells and syncytiotrophoblast cells composed of two, does not appear down. Trophoblast cells is characterized by: medium-sized cells, were polygonal, clear cytoplasm, membrane cl
ear, nuclear round the middle, sometimes nuclear vacuoles, mitotic activity. Syncytiotrophoblast characteristics: the size of the multi-core range of cells, irregular perimeter; cell cytoplasm together, and the formation of ribbon, or a group gathered in an ill-defined nucleus in the cytoplasm; nucleosome without rules, there is little division phase.
(C) of the blood and urine pregnancy test result of tumor secretion of hCG, so the blood and urine hCG levels.
(A) and non-gestational choriocarcinoma choriocarcinoma, both of which are gestational trophoblastic tumor, pathological morphology in the same, but the tissue and clinical performance is significantly different. Gestational choriocarcinoma occurs mainly in women of childbearing age, the pregnancy by the trophoblast cells from malignant transformation; rather than gestational choriocarcinoma, more common in children or young women, clinical manifestations of precocious puberty, their organization occurs when the patient''s own part in the embryonic trophoblast cell abnormalities result of the development. Ovarian and other malignancies often coexist.
(B) of ovarian pregnancy is very rare. A history of amenorrhea, and irregular vaginal bleeding. Gynecological examination can be found in ovarian tumor. When bleeding can be symptoms such as acute abdominal pain and bleeding. Were positive for hCG in urine should identify ovarian choriocarcinoma. But ovarian pregnancy occurs in women of childbearing age, symptoms and there are no signs of systemic metastases. Decidual tube of vaginal discharge may have, if necessary, assist in the diagnosis feasible diagnostic curettage.
Analysis of the genetic origin of choriocarcinoma Genetic genesis of choriocarcinomaYou can in the "My Services" in the you add a reference to the notification list, and configure access to notices.The purpose of identification by molecular analysis of genetic origin of choriocarcinoma, the nature of the (pregnant or non-gestational), while screening the causes of gestational choriocarcinoma, the nature of pregnancy. Methods A retrospective analysis of 12 patients with pathologically diagnosed as choriocarcinoma The clinical data of patients; application microdissection purified from paraffin tissue choriocarcinoma tissues, and the other patients and their husbands extracted peripheral blood DNA, were amplified by PCR application of microsatellite loci, by comparing human chorionic carcinoma with the patient and her husband amplified DNA fragment to determine the genetic origin of choriocarcinoma. Results 12 cases of choriocarcinoma patients, 7 cases of ovarian choriocarcinoma starting position (or gonads), but only 4 non- gestational choriocarcinoma, the other 3 cases of gestational choriocarcinoma; 5 patients starting position for the uterus who were confirmed by genetic analysis of gestational choriocarcinoma. This 8 cases of gestational choriocarcinoma of pregnancy causes males were isolated nature of the of complete hydatidiform mole (6 cases) and normal pregnancies (2 cases). Conclusions The detection of microsatellite polymorphisms can be clearly defined gestational choriocarcinoma or gestational, and can clear the causes of pregnancy nature. of: Zhao Jun sunny million Xi Yun-Feng Fengzhi Cui versatile YAT ZHAO JunXIANG YangWAN Xi-runFENG Feng-zhiCUI Quan-caiYANG Xiu-yu Zhao Jun, Xiangyang, Wan Xi Yun, Feng Fengzhi, YAT, ZHAO Jun, XIANG Yang , WAN Xi-run, FENG Feng-zhi, YANG Xiu-yu (Chinese Academy of Medical Sciences Peking Union Hospital of Beijing, 100730)
Cui versatile, CUI Quan-cai (Chinese Academy of Medical Sciences Department of Pathology, Union Hospital, Beijing 100730, China) Title: Journal of Obstetrics and Gynecology ISTKU English title: CHINESE JOURNAL OF OBSTETRICS AND GYNECOLOGY, the volume (of): 2010 45 (1) Classification : R73 Keywords: choriocarcinoma microsatellite repeat polymorphism genetic Choriocarcinoma: Microsatellite repeats Polymorphism, genetic unit standard DOI: R3 R78 machine standard Key words: genetic analysis of the of choriocarcinoma during pregnancy, the nature of cancer patients with complete hydatidiform molemolecular cancer tissue microdissection analysis of microsatellite loci cause of venous bloodoriginDNA complete hydatidiform mole retrospective analysis of the peripheral blood of Molecular Genetics Foundation: Higher Education Research Fund for the Doctoral Program, Beijing Science and Technology New Star Program DOI: 10.3760/cma. j.issn.0529-567x.2010.01.010 References (10) Fisher RA.Newlands ES.Joffreys AJGestational and nongestational trophoblastic tumors distinguished by DNA analysis 1992 Jun Zhao. sunny. Shang-Jyh Hwang. million hope Run. Dong Min. Hu Shao-Yi . He Lianzhi. YAT familial recurrent hydatidiform mole and genetic analysis of the clinical features [Papers] - Obstetrics and Gynecology 2006 (3) Lurain JRGestational trophoblastic tumors 1990 O''Neill CJ.Houghton F. Clarke JUterine gestational choriocarcinoma developing after a long latent period in a postmenopausal woman: the value of DNA polymorphism studies 2008 Yoon JM.Burns RC.Malognlowkin MHTreatment of infantile choriocarcinoma of the liver 2007 Minamino K. Adachi Y. Okamum AAutopsy case of primary choriocarcinoma of the urinary bladder 2005 Yang J. Xiang Y. Wan XThe prognosis of gestational trophoblastic neoplasia patient with residual lung tumor after completing treatment 2006 Balat O. Kutlar 1.Ozkur APrimary pure ovarian chorioearcinoma mimicking ectopie pregnancy: a report of fulminant progression 2004 Kohorn EINegotiating a staging and risk factor scoring system for gestational trophoblastic neoplasia: A progress report 2002 Ma Y. Xiang Y. Wan XRThe prognostic analysis of 123 postpartum choriocarcinoma cases 2008
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